The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game.

Philip Rivers makes the second start of his comeback with the Indianapolis Colts against the San Francisco 49ers on " Monday Night Football ."

Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.