In civil and structural engineering, the word “safe” is often used as the ultimate benchmark of good design. If a structure does not collapse under design loads and meets code requirements, it is ...

Figure 1: In vitro assembly of the OCCM complex. A missing piece of information is how ORC–Cdc6 recruits and interacts with Cdt1–MCM2-7 before the formation of the MCM2-7 double hexamer (Fig. 1a).

The effects of static loads (e.g. lift and maneuvers) and dynamic loads (e.g. gust encounter and/or turbulence) are analyzed in aircraft design using models and assumptions. The validation of these ...