Deregulation of p16INK4A is a critical event in melanoma susceptibility and progression. It is generally assumed that the major effect of loss of p16 function is mediated through the CDK−cyclin ...

SALT LAKE CITY – Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have generated the first “atlas” of human melanocytes located throughout the body. In analyzing the ...

Melanin is often talked about in terms of skin tone, but its role goes far beyond color. This naturally occurring pigment functions as one of the body’s most important defense systems, especially when ...

Melanosomes are specialized intracellular organelles of pigment cells in which melanin pigments are synthesized and stored. They are members of a family of cell-type-specific lysosome-related ...