San Francisco 49ers quarterback Brock Purdy was named the NFC Offensive Player of the Week for his five-touchdown game against the Indianapolis Colts.

George Kittle has a mid-to-low ankle sprain, per Jeremy Fowler. The 49ers tight end avoided a high ankle sprain ahead of Week 17 vs. Bears.

Monday Night Football in Week 16 features a battle between two playoff hopefuls in the San Francisco 49ers and Indianapolis Colts. All San Francisco has to do t

Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on Dec. 22. Who will win?

Stay up to date here with the latest news and highlights from the Indianapolis Colts' Week 16 matchup on Monday Night Football against the San Francisco 49ers.

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have officially put their playoff destiny in their own hands.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.